anti-JMJD4 antibody product blog
Tags: Antibody; Polyclonal Antibody; JMJD4; anti-JMJD4 antibody;
The JMJD4 jmjd4 (Catalog #MBS629777) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The JMJD4, NT (Jumonji Domain-containing Protein 4, JmjC Domain-containing Protein 4) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s JMJD4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:250-1:500. Researchers should empirically determine the suitability of the JMJD4 jmjd4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The JMJD4 jmjd4 product has the following accession number(s) (GI #56204643) (Uniprot Accession #Q9H9V9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the JMJD4, NT (Jumonji Domain-containing Protein 4, JmjC Domain-containing Protein 4) with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of anti-JMJD4 (N-term) Pab in HepG2 cell line lysate. JMJD4 (N-term)(arrow) was detected using the purified Pab.)
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Immunogen: Synthetic peptide selected from the N-terminal region of human JMJD4 (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing JMJD4 are readily searchable from our website. Different antibodies against the same target such as JMJD4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. JMJD4 also interacts with the following gene(s): FLNA. The following patways have been known to be associated with this gene.