|The KDM6B kdm6b (Catalog #MBS647954) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The JMJD3, ID (Kdm6b, Jmjd3, Kiaa0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji domain-containing protein 3) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s JMJD3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100. Researchers should empirically determine the suitability of the KDM6B kdm6b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The KDM6B kdm6b product has the following accession number(s) (GI #14603031) (NCBI Accession #AAH09994.1) (Uniprot Accession #O15054). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Immunogen: Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 964~993 amino acids from the center region of mouse JMJD3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing KDM6B are readily searchable from our website. Different antibodies against the same target such as KDM6B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Embryonic Tissue, Heart, Kidney, Lung, Pancreas, Prostate, Skin tissues are correlated with this protein. KDM6B also interacts with the following gene(s): ASCL1, HOXB1, SMAD1, SMAD2, SMAD3, SMAD4, TBX21. Cell Transformation, Neoplastic, Death, Inflammation, Kidney Diseases, Necrosis, Neoplasms, Nervous System Diseases, Neural Tube Defects, Prostatic Diseases, Skin Diseases are some of the diseases may be linked to JMJD3, ID (Kdm6b, Jmjd3, Kiaa0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji domain-containing protein 3).