|The KIR2DL2 kir2dl2 (Catalog #MBS9208924) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KIR2DL2 Antibody (C-Term) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s KIR2DL2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS).
FC~~1:10~50. Researchers should empirically determine the suitability of the KIR2DL2 kir2dl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The KIR2DL2 kir2dl2 product has the following accession number(s) (GI #134304833) (NCBI Accession #NP_055034.2) (Uniprot Accession #P43627). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the KIR2DL2 Antibody (C-Term) with the following immunoassay(s):
Western Blot (WB) (KIR2DL2 Antibody (C-Term) western blot analysis in MDA-MB231,Jurkat cell line lysates (35ug/lane).This demonstrates the KIR2DL2 antibody detected the KIR2DL2 protein (arrow).)
Flow Cytometry (FC/FACS) (KIR2DL2 Antibody (C-Term) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several \'framework\' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN
Function: Receptor on natural killer (NK) cells forHLA-Cw1, 3, 7, and 8 allotypes. Inhibits theactivity of NK cells thus preventing cell lysis.
Cellular Location: Cell membrane; Single-pass type I membraneprotein.