|The KNG1 kng1 (Catalog #MBS719708) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Kininogen-1 polyclonal Antibody, FITC reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Kininogen-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the KNG1 kng1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The KNG1 kng1 product has the following accession number(s) (GI #4504893) (NCBI Accession #NP_000884.1) (Uniprot Accession #P01042). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit anti-human Kininogen-1 polyclonal Antibody, FITC with the following immunoassay(s):
Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
Storage Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate: FITC. Immunogen: Recombinant human Kininogen-1 protein
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-14941 / sc-25885. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing KNG1 are readily searchable from our website. Different antibodies against the same target such as KNG1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Atherosclerosis, Carcinoma, Hepatocellular, Cardiovascular Diseases, Heart Diseases, Hypertension, Inflammation, Kidney Diseases, Liver Diseases, Nervous System Diseases, Seizures are some of the diseases may be linked to Rabbit anti-human Kininogen-1 polyclonal Antibody, FITC.