|The LILRB3 lilrb3 (Catalog #MBS2525893) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LILRB3 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s LILRB3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC).
IHC: 1:15-1:50. Researchers should empirically determine the suitability of the LILRB3 lilrb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The LILRB3 lilrb3 product has the following accession number(s) (GI #556523084) (NCBI Accession #NP_006855) (Uniprot Accession #O75022). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the LILRB3 Polyclonal Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human breast cancer tissue using LILRB3 Polyclonal Antibody at dilution 1:20)
Background: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing LILRB3 are readily searchable from our website. Different antibodies against the same target such as LILRB3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. LILRB3 also interacts with the following gene(s): FCGR3B. Blood, Bone, Lung tissues are correlated with this protein.