|The LIN28B lin28b (Catalog #MBS9404957) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LIN28B Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s LIN28B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Western blotting: 1:500~1:1000. Researchers should empirically determine the suitability of the LIN28B lin28b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The LIN28B lin28b product has the following accession number(s) (GI #51972214) (NCBI Accession #NP_001004317.1) (Uniprot Accession #Q6ZN17). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the LIN28B Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts from Hela and 293 cells using LIN28B Antibody.)
Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5\'-GGAG-3\' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5\'-GGAG-3\' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. "Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma.".
Immunogen Type: Peptide-KLH
Immunogen Description: Peptide sequence around aa.242~246(P-S-V-Q-K) derived from Human LIN28B. Target Name: LIN28B. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing LIN28B are readily searchable from our website. Different antibodies against the same target such as LIN28B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. LIN28B also interacts with the following gene(s): DICER1, LGR5, MAX, MYC, NANOG, TRIM71, ZCCHC11. Breast Neoplasms, Cell Transformation, Neoplastic, Gonadal Disorders, Inflammation, Kidney Diseases, Lung Neoplasms, Neoplasm Metastasis, Neuroblastoma, Obesity, Ovarian Neoplasms are some of the diseases may be linked to LIN28B Antibody.