anti-lmna antibody product blog
Tags: Antibody; Polyclonal Antibody; LMNA; anti-LMNA antibody; Lamin A;
The lmna lmna (Catalog #MBS837324) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Lamin A can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB).IHC: 15-20 ug/ml
WB: 0.5-4 ug/ml. Researchers should empirically determine the suitability of the lmna lmna for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The lmna lmna product has the following accession number(s) (GI #156119433) (NCBI Accession #NP_001095210.1) (Uniprot Accession #P11048). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Lamin An antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of Lamin A/C in lysates from Jurkat cells (Lane 1 & 2), mouse small intestine (Lane 3) and rat kidney (Lane 4).)
Rabbit polyclonal Lamin An antibody.
Biological Significance: Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication and chromatin organization. Lamin An is specifically cleaved by caspase-6 and therefore serves as a marker for caspase-6 activation. During apoptosis the 70 kDa lamin An is cleaved to a large and small fragment. The cleavage of lamins results in nuclear disregulation and cell death. Cross-Reactivity: Human, Mouse, Rat
Immunogen: Lamin An antibody was raised in Rabbit using synthetic peptide surrounding amino acid 220 of human Lamin An as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing lmna are readily searchable from our website. Different antibodies against the same target such as lmna may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Cardiomyopathy, Dilated, Cardiovascular Diseases, Death, Sudden, Cardiac, Heart Block, Heart Diseases, Lipodystrophy, Familial Partial, Muscular Dystrophies, Limb-Girdle, Muscular Dystrophy, Emery-Dreifuss, Nervous System Diseases, Progeria are some of the diseases may be linked to Lamin An antibody.