anti-LTBR antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-LTBR antibody; LTBR;
The LTBR ltbr (Catalog #MBS176113) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-LTBR antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s LTBR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the LTBR ltbr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The LTBR ltbr product has the following accession number(s) (GI #549090) (NCBI Accession #P36941.1) (Uniprot Accession #P36941). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-LTBR antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-LTBR antibody, MBS176113, IHC(P)
IHC(P): Human Intestinal Cancer Tissue )
Western Blot (WB) (Anti-LTBR antibody, MBS176113, Western blotting
All lanes: Anti LTBR (MBS176113) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: A549 Whole Cell Lysate at 40ug
Predicted bind size: 47KD
Observed bind size: 60KD )
Description: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 3(LTBR) detection. Tested with WB, IHC-P in Human.
Background: LTBR(Lymphotoxin B Receptor), also called TNFCR or LT-BETA-R, is a receptor for lymphotoxin which in humans is encoded by the LTBR gene. By linkage analysis with recombinant inbred mouse strains, Nakamura et al.(1995) demonstrated that the Tnfcr locus is close to the Tnfr1 gene on mouse chromosome 6. Presumably, the human homolog is located on 12p13. Silva-Santos et al.(2005) reported that double-positive T cells regulate the differentiation of early thymocyte progenitors and gamma-delta cells by a mechanism dependent on the transcription factor ROR-gamma-t and the lymphotoxin-beta receptor. Lo et al.(2007) identified lymphotoxin and LIGHT(TNFSF14), tumor necrosis factor cytokine family members that are primarily expressed on lymphocytes, as critical regulators of key enzymes that control lipid metabolism.
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human LTBR (420-435aa ATPSNRGPRNQFITHD). Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing LTBR are readily searchable from our website. Different antibodies against the same target such as LTBR may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.