anti-MAP3K7 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-MAP3K7 antibody; MAP3K7;
The MAP3K7 map3k7 (Catalog #MBS9403802) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MAP3K7 (Phospho-Thr187) Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s MAP3K7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Western blotting: 1:500~1:1000. Researchers should empirically determine the suitability of the MAP3K7 map3k7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MAP3K7 map3k7 product has the following accession number(s) (GI #4507361) (NCBI Accession #NP_003179.1) (Uniprot Accession #O43318). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MAP3K7 (Phospho-Thr187) Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts from NIH-3T3 tissue using MAP3K7 (Phospho-Thr187) antibody.The lane on the right is treated with the antigen-specific peptide.)
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7.Shin MS, et al. (2009)Biochim Biophys Acta 1793, 1156-64 Liu Q, Busby JC, Molkentin JD (2009)Nat Cell Biol 11, 154-61 Kim SI, Kwak JH, Wang L, Choi ME (2008)J Biol Chem 283, 10753-63.
Immunogen Type: Peptide-KLH
Immunogen Description: Peptide sequence around phosphorylation site of threonine 187 (H-M-T(p)-N-N) derived from Human MAP3K7. Modification: Phospho-Thr187
Target Name: MAP3K7. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MAP3K7 are readily searchable from our website. Different antibodies against the same target such as MAP3K7 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.