|The MAPK8IP1 mapk8ip1 (Catalog #MBS9414359) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MAPK8IP1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s MAPK8IP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Western blotting: 1:200-1:1000. Researchers should empirically determine the suitability of the MAPK8IP1 mapk8ip1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MAPK8IP1 mapk8ip1 product has the following accession number(s) (GI #4885433) (NCBI Accession #NP_005447.1) (Uniprot Accession #Q9UQF2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MAPK8IP1 Antibody with the following immunoassay(s):
Testing Data (Gel: 6%SDS-PAGE Lysates (from left to right): Mouse kidney tissue)
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Immunogen Type: Peptide
Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human mitogen-activated protein kinase 8 interacting protein 1. Target Name: MAPK8IP1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MAPK8IP1 are readily searchable from our website. Different antibodies against the same target such as MAPK8IP1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. MAPK8IP1 also interacts with the following gene(s): AKT1, APP, FYN, KLC1, LRP8, MAP2K7, MAPK8, MAPK8IP3.