|The MAVS mavs (Catalog #MBS610711) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Mitochondrial Antiviral Signaling Protein (MAVS, VISA) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Mitochondrial Antiviral Signaling Protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF).
Dilution: Western Blot: 1:1000
Immunofluorescence (IF-IC): 1:50. Researchers should empirically determine the suitability of the MAVS mavs for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MAVS mavs product has the following accession number(s) (GI #83776598) (NCBI Accession #NP_065797.2) (Uniprot Accession #Q7Z434). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The mitochondrial antiviral signaling protein (MAVS, VISA) contributes to innate immunity by triggering IRF-3 and NF- B activation in response to viral infection, leading to the production of IFN- (1). The MAVS protein contains an N-terminal CARD domain and a C-terminal mitochondrial transmembrane domain. The MAVS adaptor protein plays a critical and specific role in viral defenses (2). MAVS acts downstream of the RIG-I RNA helicase and viral RNA sensor, leading to the recruitment of IKK, TRIF and TRAF6 (3,4). Some viruses have evolved strategies to circumvent these innate defenses by using proteases that cleave MAVS to prevent its mitochondrial localization (5,6).
Immunogen: Synthetic peptide (KLH-coupled) corresponding to residues at the carboxyl terminus of human MAVS. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MAVS are readily searchable from our website. Different antibodies against the same target such as MAVS may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. MAVS also interacts with the following gene(s): DDX58, IRF3, IRF7, TBK1, TRAF6. Blood, Bone, Heart, Kidney, Liver, Lung, Muscle, Nerve, Spleen, Vascular tissues are correlated with this protein. Anemia, Congenital Abnormalities, Fibrosis, Hemorrhage, Hypertension, Inflammation, Liver Neoplasms, Lung Neoplasms, Myocardial Ischemia, Nervous System Malformations are some of the diseases may be linked to Mitochondrial Antiviral Signaling Protein (MAVS, VISA). The following patways have been known to be associated with this gene.