|The MBD2 mbd2 (Catalog #MBS9213629) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MBD2 Antibody (N-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s MBD2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).
WB~~1:1000. Researchers should empirically determine the suitability of the MBD2 mbd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MBD2 mbd2 product has the following accession number(s) (GI #4505117) (NCBI Accession #NP_003918.1) (Uniprot Accession #Q9UBB5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MBD2 Antibody (N-term) with the following immunoassay(s):
Western Blot (WB) (The anti-MBD2 N-term Antibody is used in Western blot to detect MBD2 in A375 cell lysate (lane 1) and mouse brain tissue lysate (lane 2) lysate.)
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MBD2 are readily searchable from our website. Different antibodies against the same target such as MBD2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Breast Neoplasms, Carcinoma, Hepatocellular, Disease Models, Animal, Liver Diseases, Liver Neoplasms, Lung Diseases, Neoplasm Metastasis, Neoplasms, Experimental, Neurobehavioral Manifestations, Prostatic Neoplasms are some of the diseases may be linked to MBD2 Antibody (N-term). MBD2 also interacts with the following gene(s): CHD3, DNMT1, GATAD2A, HDAC1, HDAC2, MBD3, MTA2, PRMT5, RBBP4, SIN3A.