|The MC1R mc1r (Catalog #MBS9404753) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MC1R antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s MC1R can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:200. Researchers should empirically determine the suitability of the MC1R mc1r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MC1R mc1r product has the following accession number(s) (GI #193083134) (NCBI Accession #NP_002377.4) (Uniprot Accession #Q01726). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MC1R antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of mouse intestine tissue lysate, using MC1R antibody.)
Immunohistochemistry (IHC) (Immunohistochemistry analysis of paraffin-embedded human kidney cancer tissue using MC1R antibody at dilution of 1:200 (x400 lens))
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer.
Immunogen Type: Peptide
Immunogen Description: A synthetic peptide of human MC1R. Target Name: MC1R. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MC1R are readily searchable from our website. Different antibodies against the same target such as MC1R may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bone, Brain, Connective Tissue, Eye, Intestine, Kidney, Liver, Muscle, Skin, Vascular tissues are correlated with this protein.