anti-MERTK antibody product blog
Tags: Antibody; Polyclonal Antibody; MERTK; anti-MERTK antibody;
The MERTK mertk (Catalog #MBS1493353) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MERTK Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s MERTK can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC).Recommended dilution: WB:1:200-1000
IHC:1:20-1:200. Researchers should empirically determine the suitability of the MERTK mertk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MERTK mertk product has the following accession number(s) (GI #66932918) (NCBI Accession #NP_006334.2) (Uniprot Accession #Q12866). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MERTK Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot
All lanes: MERTK antibody at 10ug/ml
Lane 1:mouse gonad tissue
Lane 2:mouse lung tissue
Lane 3:mouse kidney tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 110kDa
Observed band size: 110kDa
)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human endometrial cancer using MBS1493353 at dilution 1:100)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS1493353 at dilution 1:100)
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate: Non-conjugated. Immunogen: Recombinant human Tyrosine-protein kinase Mer protein (840-999aa)
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-66395 / sc-66397 / sc-67281. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MERTK are readily searchable from our website. Different antibodies against the same target such as MERTK may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.