|The MFN1 mfn1 (Catalog #MBS153700) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MFN1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s MFN1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC).
MFN1 antibody can be used for detection of MFN1 by Western blot at 1 - 2 mug/ml. Antibody can also be used for Immunocytochemistry at 5 mug/mL. Researchers should empirically determine the suitability of the MFN1 mfn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MFN1 mfn1 product has the following accession number(s) (GI #45269137) (NCBI Accession #NP_284941) (Uniprot Accession #Q8IWA4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MFN1 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of MFN1 in A431 cell lysate with MFN1 antibody at 1 μg/ml.)
Immunocytochemistry (ICC) (Immunocytochemistry of MFN1 in A431 cells with MFN1 antibody at 5 μg/mL.)
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2). MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development (3). When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane (4).
Immunogen: MFN1 antibody was raised against a 17 amino acid peptide near the amino terminus of human MFN1.
Buffer: MFN1 antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MFN1 are readily searchable from our website. Different antibodies against the same target such as MFN1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. MFN1 also interacts with the following gene(s): BAK1, DNM1L, FIS1, GDAP1, MARCH5, MAVS, PARK2, PHB2. Blood, Bone, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung, Muscle, Nerve tissues are correlated with this protein.