anti-MMP-2 antibody product blog
Tags: Antibody; Polyclonal Antibody; MMP-2; anti-MMP-2 antibody;
The MMP-2 mmp2 (Catalog #MBS2538300) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MMP-2 Polyclonal Antibody reacts with Human, Mouse, Rat, Monkey and may cross-react with other species as described in the data sheet. MyBioSource\'s MMP-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA).WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:50-1:100
ELISA: 1:5000-1:20000. Researchers should empirically determine the suitability of the MMP-2 mmp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MMP-2 mmp2 product has the following accession number(s) (GI #8050250) (NCBI Accession #AAF71618.1) (Uniprot Accession #P08253). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MMP-2 Polyclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HT-29 cells using MMP-2 Polyclonal Antibody at dilution of 1:1000.)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human liver cancer tissue using MMP-2 Polyclonal Antibody at dilution of 1:200.)
Immunofluorescence (IF) (Immunofluorescence analysis of Rat lung tissue using MMP-2 Polyclonal Antibody at dilution of 1:200.)
Background: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro.PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MMP-2 are readily searchable from our website. Different antibodies against the same target such as MMP-2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Artery, Brain, Connective Tissue, Embryonic Tissue, Eye, Heart, Lung, Muscle, Placenta, Prostate tissues are correlated with this protein.