anti-MRE11A antibody product blog
Tags: Antibody; Polyclonal Antibody; Mre11; anti-Mre11a antibody; Mre11a;
The MRE11A mre11a (Catalog #MBS150224) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MRE11 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s MRE11 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).MRE11 antibody can be used for detection of MRE11 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the MRE11A mre11a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MRE11A mre11a product has the following accession number(s) (GI #119587336) (NCBI Accession #EAW66932) (Uniprot Accession #P49959). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MRE11 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of MRE11 in A549 cell lysate with MRE11 antibody at (A) 1 and (B) 2 μg/mL.)
Immunohistochemistry (IHC) (Immunohistochemistry of MRE11 in rat lung tissue with MRE11 antibody at 5 μg/mL.)
Immunofluorescence (IF) (Immunofluorescence of MRE11 in rat lung tissue with MRE11 antibody at 20 μg/mL.)
MRE11 Antibody: MRE11 is involved in the repair of DNA double strand breaks as part of a complex that includes the Rad50 and NBS1 protein and is thought to act in the same pathway as the A-T mutated (ATM) protein. By itself, the protein has 3\' to 5\' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for non-homologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3\' to 5\' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Mutations in this protein result in a novel ataxia telangiectasia-like disorder (ATLD). Unlike the ATM protein, MRE11 is necessary proper mammalian development.
Conjugate: Unconjugated
Immunogen: MRE11 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus human MRE11.
Buffer: MRE11 Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MRE11A are readily searchable from our website. Different antibodies against the same target such as MRE11A may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.