anti-MSI1 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-MSI1 antibody; MSI1; Musashi-1 RNA Binding Protein;
The MSI1 msi1 (Catalog #MBS614414) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Musashi-1 RNA Binding Protein (Mi, Msi-1) reacts with Human, Rodent and may cross-react with other species as described in the data sheet. MyBioSource\'s Musashi-1 RNA Binding Protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC).Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.
Dilution: Western Blot: 1:200-1:1000 (ECL)
Immunohistochemistry(Frozen sections. Not tested for paraffin): 1:200-1:1000
Immunocytochemistry: 1:200-1:1000. Researchers should empirically determine the suitability of the MSI1 msi1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MSI1 msi1 product has the following accession number(s) (GI #3786320) (NCBI Accession #BAA33962.1) (Uniprot Accession #O43347). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Musashi-1 RNA Binding Protein (Mi, Msi-1) with the following immunoassay(s):
Chemiluminescence (1:1000 dilution of this lot detected Musashi-1 on 10ug of Human placenta lysates. Human placenta lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with MBS614414 (1:1000 dilution of this lot). Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates Musashi 1(~39kD))
Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia and Parkinson\'s. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 other neurodegenerative diseases Alzheimer\'s disease and Pick disease suggests that it may play a role in the pathogenesis of these neurodegenerative disorders. Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play a vital role in the development of several types of carcinoma such as human hepatoma and may be an useful molecular marker for tumor detection.
Immunogen: Synthetic peptide, amino acids 5-21 of Musashi. MW: 39.121kD. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MSI1 are readily searchable from our website. Different antibodies against the same target such as MSI1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.