anti-MSI1 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-MSI1 antibody; MSI1; Musashi-1 RNA Binding Protein;
The MSI1 msi1 (Catalog #MBS614730) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Musashi-1 RNA Binding Protein (Mi, Msi-1) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Musashi-1 RNA Binding Protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunocytochemistry (ICC).Suitable for use in ELISA and Immunocytochemistry.
Dilution: Immunocytochemistry: 1:100. Researchers should empirically determine the suitability of the MSI1 msi1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MSI1 msi1 product has the following accession number(s) (GI #3786320) (NCBI Accession #BAA33962.1) (Uniprot Accession #O43347). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Musashi-1 RNA Binding Protein (Mi, Msi-1) with the following immunoassay(s):
Testing Data (Musashi (green) staining of neural rosettes(human). Nuclei are counterstained blue (DAPI).)
Immunohistochemistry (IHC) (Musashi-positive cells in the ventricular zone of E14.5 mouse medulla. Picture was taken at 200x magnification. The sections are 4% PFA fixed, paraffin-embedded and cut at 5 micron.)
Testing Data (Immunostaining of STEMEZ(TM) hNP1 Progenitors before and after differentiation. The culture was highly homogenous with neural rosettes. (A) Neural rosettes (white arrows, bright field) from WA09 cells. A similar result also obtained with BG02 cell line. (B) Shown here, a neural rosette stained with Nestin (NES) (green) antibody. Propagated Neural progenitors showed expression of marker genes, NES (C) and Musashi 1 (D) but not SOX2 (E). Further differentiation produced neurons (Tuj1) (F), astrocytes (GFAP) (G) and oligodendrocytes (myelin basic protein)(H) (lower panel). DAPI (blue) was used for staining the nuclei (scale bar for (A) through (E) is 100 mm and for the remaining figures 10 mm). Differentiation (2007) DOI: 10.1111/j.1432-0436.2007.00256.x..Dilutions: NES (1:100, Edina, MN), MSI1 (1:100), Tuj1 (1:500).)
Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia and Parkinson\'s. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 other neurodegenerative diseases Alzheimer\'s disease and Pick disease suggests that it may play a role in the pathogenesis of these neurodegenerative disorders. Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play a vital role in the development of several types of carcinoma such as human hepatoma and may be an useful molecular marker for tumor detection.