|The MTM1 mtm1 (Catalog #MBS9202457) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MTM1 Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s MTM1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).
WB~~1:1000. Researchers should empirically determine the suitability of the MTM1 mtm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MTM1 mtm1 product has the following accession number(s) (GI #4557896) (NCBI Accession #NP_000243.1) (Uniprot Accession #Q13496). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MTM1 Antibody (C-term) with the following immunoassay(s):
Western Blot (WB) (The anti-MTM1 C-term Pab is used in Western blot to detect MTM1 in NCI-H460 cell lysate (lane 1) and in mouse heart tissue lysate (lane 2).)
Western Blot (WB) (Western blot showing knockdown of endogenous MTM1 expression by MTM1-targeting vectors pDM134 and pDM170. Embryonic stem (ES) cells were untreated (lane 1) or transfected with control plasmid pDCont (lane 2), MTM1-targeting plasmid pDM134 (lane 3), or pDM170 (lane 4). The blot was probed with anti-MTM1 rabbit polyclonal antibodies. -Actin was used as a loading control.)
MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI(3)P). Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI(3)P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI(3)P.
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MTM1 are readily searchable from our website. Different antibodies against the same target such as MTM1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Atrophy, Brain Diseases, Heart Diseases, Hypertrophy, MYOPATHY, CENTRONUCLEAR, X-LINKED, Muscular Diseases, Myopathies, Structural, Congenital, Nervous System Diseases, Peripheral Nervous System Diseases, Urogenital Abnormalities are some of the diseases may be linked to MTM1 Antibody (C-term).