anti-MUTYH antibody product blog
Tags: Antibody; Polyclonal Antibody; MUTYH; anti-MUTYH antibody;
The MUTYH mutyh (Catalog #MBS9410781) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MUTYH antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s MUTYH can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF).Western blotting: 1:500 - 1:2000
Immunofluorescence: 1:50 - 1:200. Researchers should empirically determine the suitability of the MUTYH mutyh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MUTYH mutyh product has the following accession number(s) (GI #115298648) (NCBI Accession #NP_001041636.1) (Uniprot Accession #Q9UIF7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MUTYH antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of various cell lines, using MUTYH antibody.)
Immunofluorescence (IF) (Immunofluorescence analysis of U20S cell using MUTYH antibody. Blue: DAPI for nuclear staining.)
Base excision repair (BER) proteins catalyze the removal of incorrect or damaged bases, including oxidized bases, from DNA. N-glycosylases specific to a given lesion remove the incorrect base as the first step in BER. MYH is the mammalian ortholog of E. coli MutY, a DNA glycosylase that catalyzes the removal of 8-oxoG:A mismatches (1). Several MYH isoforms have been detected in human cells localizing to either the nucleus or the mitochondria (2). MYH interacts with DNA repair proteins and localizes to DNA damage foci after oxidative damage (3). Research studies have shown that mutations in the corresponding MYH gene are associated with human gastric (4) and colorectal (5-7) cancers.
Immunogen Type: Recombinant Protein
Immunogen Description: Recombinant protein of human MUTYH. Target Name: MUTYH. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MUTYH are readily searchable from our website. Different antibodies against the same target such as MUTYH may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. MUTYH also interacts with the following gene(s): APEX1, APEX2, HUS1, MLH1, MSH2, MSH6, NTHL1, NUDT1, OGG1, PCNA. Adenocarcinoma, Adenomatous Polyposis Coli, Breast Neoplasms, Carcinoma, Chromosome Aberrations, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasms, Experimental, Ovarian Neoplasms are some of the diseases may be linked to MUTYH antibody.