anti-NBN antibody product blog
Tags: Antibody; Polyclonal Antibody; NBN; anti-NBN antibody; Nibrin, p95,;
The NBN nbn (Catalog #MBS622364) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Nibrin, p95, (Nijmegen Breakage Syndrome, NBS1) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Nibrin, p95, can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF).Suitable for use in Immunofluorescence, Western Blotting, Immunoprecipitation.
Dilution: Immunofluorescence: 1:200-1:500
Western Blotting: 1:5000-1:10,000. ~95kD
Immunoprecipitation: Methanol-fixed IMR90 primary human fibroblasts, ~3-x10e6 cells. Researchers should empirically determine the suitability of the NBN nbn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NBN nbn product has the following accession number(s) (GI #33356172) (NCBI Accession #NP_002476.2) (Uniprot Accession #O60934). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
Immunogen: Nibrin, p95 (Nijmegen Breakage Syndrome, NBS1). Positive Control: Hela whole cell extract, TK6 cell lysates. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NBN are readily searchable from our website. Different antibodies against the same target such as NBN may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. NBN also interacts with the following gene(s): ATM, BRCA1, H2AFX, MDC1, MDM2, MRE11A, NFBD1, RAD50, SIRT1. The following patways have been known to be associated with this gene. Anemia, Breast Neoplasms, Carcinoma, Cardiovascular Diseases, Colorectal Neoplasms, Leukemia, Neoplasms, Nervous System Diseases, Nijmegen Breakage Syndrome, Ovarian Neoplasms are some of the diseases may be linked to Nibrin, p95, (Nijmegen Breakage Syndrome, NBS1). Bladder, Blood, Bone, Brain, Eye, Kidney, Liver, Lung, Prostate, Skin tissues are correlated with this protein.