anti-NLRP3 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-NLRP3 antibody; NLRP3;
The NLRP3 nlrp3 (Catalog #MBS2523957) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NLRP3 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s NLRP3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).WB: 1:200-1:1000. Researchers should empirically determine the suitability of the NLRP3 nlrp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NLRP3 nlrp3 product has the following accession number(s) (GI #341865590) (NCBI Accession #BC117211) (Uniprot Accession #Q96P20). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the NLRP3 Polyclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of K562 and hela cell using NLRP3 Polyclonal Antibody at dilution of 1:88)
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5\' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5\' UTR splice patterns are biologically valid.
Immunogen: Recombinant protein of human NLRP3. Note: Centrifuge before opening to ensure complete recovery of vial contents. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NLRP3 are readily searchable from our website. Different antibodies against the same target such as NLRP3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone Marrow, Brain, Connective Tissue, Intestine, Lung, Pancreas, Prostate, Thymus tissues are correlated with this protein.