|The NOG nog (Catalog #MBS355051) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Noggin antibody reacts with Human, rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Noggin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC).
WB (1:2000); ICC (1:100-200). Researchers should empirically determine the suitability of the NOG nog for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NOG nog product has the following accession number(s) (GI #4885523) (NCBI Accession #NP_005441.1) (Uniprot Accession #Q13253). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Noggin antibody with the following immunoassay(s):
Western Blot (WB)
Noggin, also known as NOG, is a protein which in humans is encoded by the NOG gene which maps to chromosome 17q22.  Noggin binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, noggin may have a principal role in creating morphogenic gradients.  It plays a key role in neural induction by inhibiting BMP4, along with other TGF-beta signaling inhibitors such as chord in and follistatin.
Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the region of Noggin. Storage Buffer: In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide
Storage Buffer: In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NOG are readily searchable from our website. Different antibodies against the same target such as NOG may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Inflammation, Liver Diseases, Liver Neoplasms, Liver Neoplasms, Experimental, Neoplasm Metastasis, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to Anti-Noggin antibody. NOG also interacts with the following gene(s): BMP2, BMP4, BMP6, BMP7, BMPR1A, BMPR1B, BMPR2, GDF5. Blood, Brain, Placenta, Prostate, Spleen, Uterus tissues are correlated with this protein. The following patways have been known to be associated with this gene.