anti-NOX4 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-NOX4 antibody; NOX4;
The NOX4 nox4 (Catalog #MBS7003858) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NOX4 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s NOX4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF). Researchers should empirically determine the suitability of the NOX4 nox4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The NOX4 nox4 product has the following accession number(s) (GI #219842346) (NCBI Accession #NP_001137308.1) (Uniprot Accession #Q9NPH5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the NOX4 Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7003858 at dilution of 1:100)
Immunofluorescence (IF) (Immunofluorescent analysis of HepG2 cells using MBS7003858 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.
Immunogen: Recombinant human NADPH oxidase 4 protein. Conjugation: Non-conjugated
Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-21860 / sc-55142 / sc-30141. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NOX4 are readily searchable from our website. Different antibodies against the same target such as NOX4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Brain, Connective Tissue, Embryonic Tissue, Eye, Intestine, Kidney, Mouth, Pancreas, Placenta, Vascular tissues are correlated with this protein. Atherosclerosis, Cardiovascular Diseases, Fibrosis, Heart Diseases, Hypertension, Hypertrophy, Inflammation, Kidney Diseases, Necrosis, Vascular Diseases are some of the diseases may be linked to NOX4 Antibody.