anti-NQO1 antibody product blog
Tags: Antibody; Polyclonal Antibody; NQO1; anti-NQO1 antibody;
The NQO1 nqo1 (Catalog #MBS9414157) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NQO1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s NQO1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100. Researchers should empirically determine the suitability of the NQO1 nqo1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NQO1 nqo1 product has the following accession number(s) (GI #4505415) (NCBI Accession #NP_000894.1) (Uniprot Accession #P15559). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the NQO1 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of various cell lines, using NQO1 antibody.)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human thyroid cancer using NQO1 antibody at dilution of 1:200 (200x lens).)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human kidney using NQO1 antibody at dilution of 1:200 (200x lens).)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human rectal cancer using NQO1 antibody at dilution of 1:200 (200x lens).)
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the two-electron reduction of quinones and their derivatives (1,2). This enzyme protects cells against redox cycling and oxidative stress (1,3). The expression of NQO1 is increased in liver, colon and breast tumors and non-small cell lung cancer (NSCLC) compared with the normal tissues (1,2). Moreover, expression levels are also elevated in developing tumors, suggesting a role for NQ01 in the prevention of tumor development (1). Studies on NQO1 knockout mice suggest that the lack of NQO1 enzymatic activity changes intracellular redox states resulting in a reduction in apoptosis, which in turns leads to myeloid hyperplasia of bone marrow (2).
Immunogen Type: Peptide
Immunogen Description: A synthetic peptide of human NQO1. Target Name: NQO1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NQO1 are readily searchable from our website. Different antibodies against the same target such as NQO1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.