anti-PAR-1 antibody product blog
Tags: Antibody; Polyclonal Antibody; PAR-1; PAR-1 / MARK2; anti-PAR-1 antibody;
The PAR-1 mark2 (Catalog #MBS243933) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal (IgG) to Human PAR-1 / MARK2 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s PAR-1 / MARK2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), ELISA (EIA).ELISA (1:5000), IF (1:100 - 1:500), IHC-P (10 ug/ml). Researchers should empirically determine the suitability of the PAR-1 mark2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PAR-1 mark2 product has the following accession number(s) (GI #86990441) (NCBI Accession #NP_059672.2) (Uniprot Accession #Q7KZI7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit Polyclonal (IgG) to Human PAR-1 / MARK2 with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-MARK2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Immunofluorescence (IF) (Immunofluorescence of HUVEC cells, using MARK2 antibody. The picture on the right is treated with the synthesized peptide.)
MARK2 (EMK1), a MARK type protein kinase, has been implicated in regulating polarity, cell cycle progression, and microtubule dynamics. Specifically, it is reported to phosphorylate a MAP4-related protein in vitro. EMK(-/-) mice display growth retardation and immune cell dysfunction, and disease development in these animals has suggested that loss of EMK may contribute to autoimmune disease in mammals.
Target Species: Human
Immunogen Description: Synthetic peptide from human MARK2 (aa562-611). Immunogen: PAR-1 / MARK2 antibody was raised against synthetic peptide from human MARK2 (aa562-611).
Antigen Modification: aa562-611. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PAR-1 are readily searchable from our website. Different antibodies against the same target such as PAR-1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. PAR-1 also interacts with the following gene(s): ARHGEF2, KIAA0802, MARK4, STK11. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Nerve, Vascular tissues are correlated with this protein. Adenocarcinoma, Carcinoma, Cardiovascular Diseases, Fatty Liver, Immune System Diseases, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Stroke are some of the diseases may be linked to Rabbit Polyclonal (IgG) to Human PAR-1 / MARK2.