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anti-PARP1 antibody product blog

Posted on 2015-09-25 21:10:04 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; PARP1; anti-PARP1 antibody; Cleaved-PARP;
The PARP1 parp1 (Catalog #MBS9404799) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cleaved-PARP antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Cleaved-PARP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
WB: 1:500-1:2000. Researchers should empirically determine the suitability of the PARP1 parp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The PARP1 parp1 product has the following accession number(s) (GI #156523968) (NCBI Accession #NP_001609.2) (Uniprot Accession #P09874). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Cleaved-PARP antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts from A549 cells,The lane on the left is treated with the antigen-specific peptide.)
Western Blot (WB) PARP1.

Nvolved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

Target Name: Cleaved-PARP. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PARP1 are readily searchable from our website. Different antibodies against the same target such as PARP1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Brain Ischemia, Breast Neoplasms, Heart Diseases, Inflammation, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Necrosis, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to Cleaved-PARP antibody. PARP1 also interacts with the following gene(s): CASP3, CASP7, PARG, PCNA, TP53, UBC, WRN, XRCC1, XRCC5, XRCC6. Blood, Brain, Heart, Kidney, Liver, Lung, Muscle, Nerve, Prostate, Vascular tissues are correlated with this protein.
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