|The PHLPP1 phlpp1 (Catalog #MBS2525370) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PHLPP1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s PHLPP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC).
IHC: 1:25-1:100. Researchers should empirically determine the suitability of the PHLPP1 phlpp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PHLPP1 phlpp1 product has the following accession number(s) (GI #291219891) (NCBI Accession #NP_919431.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PHLPP1 Polyclonal Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human liver cancer tissue using PHLPP1 Polyclonal Antibody at dilution 1:35)
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
Immunogen: Recombinant protein of human PHLPP1. Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PHLPP1 are readily searchable from our website. Different antibodies against the same target such as PHLPP1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Brain, Eye, Intestine, Liver, Lung, Lymph Node, Muscle, Nerve, Prostate tissues are correlated with this protein. PHLPP1 also interacts with the following gene(s): AKT1, AKT2, PHLPP2, SCRIB, SUGT1, USP12, USP46. Breast Neoplasms, Cardiovascular Diseases, Cell Transformation, Neoplastic, Cognition Disorders, Hypertrophy, Immune System Diseases, Lung Neoplasms, Memory Disorders, Nervous System Diseases, Neurotoxicity Syndromes are some of the diseases may be linked to PHLPP1 Polyclonal Antibody.