anti-PID antibody product blog
Tags: Antibody; Polyclonal Antibody; PID; anti-PID antibody;
The PID mta2 (Catalog #MBS9407114) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PID Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s PID can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the PID mta2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The PID mta2 product has the following accession number(s) (GI #9931638) (NCBI Accession #AAG02241). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PID Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of PID expression in HeLa whole cell lysates in the absence (A) or presence (B) of blocking peptide with PID antibody at 1 ug /ml.)
Immunocytochemistry (ICC) (Immunocytochemistry staining of HeLa using PID antibody at 10 ug/mL.)
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex. PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis. PID/MTA2 is ubiquitously expressed in human tissues.
Immunogen Type: Peptide
Immunogen Description: Raised against a synthetic peptide corresponding to amino acids 652 to 668 of human PID (6), which differ from the mouse sequence by one amino acid. Target Name: PID. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PID are readily searchable from our website. Different antibodies against the same target such as PID may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. PID also interacts with the following gene(s): CHD3, CHD4, GATAD2A, HDAC1, HDAC2, MBD2, MBD3, RBBP4, RBBP7, SIN3A.