anti-PKR antibody product blog
Tags: Antibody; Polyclonal Antibody; PKR; anti-PKR antibody;
The PKR eif2ak2 (Catalog #MBS9408653) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PKR (Phospho-Thr451) Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s PKR can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC).Immunohistochemistry: 1:50~1:100. Researchers should empirically determine the suitability of the PKR eif2ak2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PKR eif2ak2 product has the following accession number(s) (GI #208431827) (NCBI Accession #NP_001129123.1) (Uniprot Accession #P19525). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PKR (Phospho-Thr451) Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using PKR(Phospho-Thr451) Antibody (left) or the same antibody preincubated with blocking peptide(right).)
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
Immunogen Type: Peptide-KLH
Immunogen Description: Peptide sequence around phosphorylation site of threonine 451 (K-G-T(p)-L-R) derived from Human PKR. Modification: Phospho-Thr451
Target Name: PKR. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PKR are readily searchable from our website. Different antibodies against the same target such as PKR may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Liver, Lung, Lymph Node, Muscle, Skin, Uterus tissues are correlated with this protein. The following patways have been known to be associated with this gene. Brain Diseases, Carcinoma, Hepatocellular, Disease Models, Animal, Fatty Liver, Inflammation, Liver Diseases, Lung Diseases, Necrosis, Nervous System Diseases, Weight Gain are some of the diseases may be linked to PKR (Phospho-Thr451) Antibody. PKR also interacts with the following gene(s): EIF2A, EIF2S1, STAT3.