|The PLEKHA1 plekha1 (Catalog #MBS6010600) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PLEKHA1 (Pleckstrin Homology Domain-containing Family A Member 1, PH Domain-containing Family A Member 1, TAPP1, Tandem PH Domain-containing Protein 1, TAPP-1) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s PLEKHA1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Suitable for use in Western Blot. Researchers should empirically determine the suitability of the PLEKHA1 plekha1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PLEKHA1 plekha1 product has the following accession number(s) (GI #307344641) (NCBI Accession #NP_001182537.1) (Uniprot Accession #Q9HB21). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
MPYVDRQNRI CGFLDIEENE NSGKFLRRYF ILDTREDSFV WYMDNPQNLP SGSSRVGAIK LTYISKVSDA TKLRPKAEFC FVMNAGMRKY FLQANDQQDL VEWVNVLNKA IKITVPKQSD SQPNSDNLSR HGECGKKQVS YRTDIVGGVP IITPTQKEEV NECGESIDRN NLKRSQSHLP YFTPKPPQDS AVIKAGYCVK QGAVMKNWKR RYFQLDENTI GYFKSELEKE PLRVIPLKEV HKVQECKQSD IMMRDNLFEI VTTSRTFYVQ ADSPEEMHSW IKAVSGAIVA QRGPGRSASS EHPPGPSESK HAFRPTNAAT ATSHSTASRS NSLVSTFTME KRGFYESLAK VKPGNFKVQT VSPREPASKV TEQALLRPQS KNGPQEKDCD LVDLDDASLP VSDV.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
Immunogen: Full length human PLEKHA1, aa1-404 (NP_001001974.1). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PLEKHA1 are readily searchable from our website. Different antibodies against the same target such as PLEKHA1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Kidney Diseases, Macular Degeneration, Age-Related, 1, Neoplasms, Nervous System Diseases are some of the diseases may be linked to PLEKHA1 (Pleckstrin Homology Domain-containing Family A Member 1, PH Domain-containing Family A Member 1, TAPP1, Tandem PH Domain-containing Protein 1, TAPP-1). Brain, Embryonic Tissue tissues are correlated with this protein. PLEKHA1 also interacts with the following gene(s): CFH, ELOVL4, HMCN1, HTRA1, MPDZ, PLEKHA2, PTPN13.