|The PLK3 plk3 (Catalog #MBS613495) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Plk3 (CNK, FNK, PRK, Polo-like Kinase 3) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Plk3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1ug/ml. Researchers should empirically determine the suitability of the PLK3 plk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PLK3 plk3 product has the following accession number(s) (GI #55961083) (Uniprot Accession #Q9H4B4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Polo-like kinases are critical regulators of cell cycle progression, cytokinesis, mitosis, and the genotoxic stress response. Four distinct members have been identified to date in mammalian cells: PLK-1, PLK-2, PLK-3, and PLK-4. PLK-3 (polo-like kinase 3) plays an important role in cell cycle regulation by modulating microtubule dynamics and centrosomal function. Although protein levels are unchanged throughout the cell cycle, kinase activity peaks during late S and G2 phases. Many key cell cycle regulators are phosphorylated by PLK-3 including p53 on Ser20, Cdc25C on Ser216, and the major subunit of DNA polymerase delta, p125 on Ser60.
Immunogen: E. coli-derived recombinant human PLK-3 (aa320-520) GenBank Accession #BC013899. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PLK3 are readily searchable from our website. Different antibodies against the same target such as PLK3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. PLK3 also interacts with the following gene(s): CDC25C, CIB1, MAP2K1, MAPK1, TP53. Blood, Bone, Bone Marrow, Brain, Eye, Intestine, Lung, Skin, Thymus, Thyroid tissues are correlated with this protein. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cardiovascular Diseases, Cell Transformation, Neoplastic, Central Nervous System Diseases, Drug Toxicity, Lung Neoplasms, Neoplasms, Neuroblastoma are some of the diseases may be linked to Plk3 (CNK, FNK, PRK, Polo-like Kinase 3).