anti-POLE antibody product blog
Tags: Antibody; Polyclonal Antibody; pole; anti-POLE antibody;
The POLE n/a (Catalog #MBS624218) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The POLE (Polymerase (DNA Directed), epsilon), DKFZp434F222, DNA Polymerase epsilon Catalytic Subunit A, DNA Polymerase II Subunit A, FLJ21434, POLE1) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s POLE can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF).Suitable for use in Western Blot and Immunofluorescence. Researchers should empirically determine the suitability of the POLE n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The POLE n/a product has the following accession number(s) (GI #18204295) (Uniprot Accession #Q8WU23). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
POLE belongs to the DNA polymerase type-B family. It participates in DNA repair and in chromosomal DNA replication. The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme. POLE consists of two subunits, 258kD and 55kD.
Immunogen: POLE (AAH21559, 1-371aa) full-length human protein. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing POLE are readily searchable from our website. Different antibodies against the same target such as POLE may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Embryonic Tissue, Eye, Heart, Kidney, Liver, Muscle, Skin tissues are correlated with this protein. Adenocarcinoma, Atrophy, Brain Diseases, Carcinoma, Congenital Abnormalities, Hemorrhage, Hypertension, Kidney Diseases, Necrosis, Neoplasms are some of the diseases may be linked to POLE (Polymerase (DNA Directed), epsilon), DKFZp434F222, DNA Polymerase epsilon Catalytic Subunit A, DNA Polymerase II Subunit A, FLJ21434, POLE1). POLE also interacts with the following gene(s): MDM2, PCNA, POLE4, RAD17. The following patways have been known to be associated with this gene.