anti-PPP1R1B antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-PPP1R1B antibody; PPP1R1B; DARPP32;
The PPP1R1B ppp1r1b (Catalog #MBS627953) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DARPP32, phosphorylated (Thr75) (Protein Phosphatase 1 Regulatory Subunit 1B, DARPP-32, Dopamine- and cAMP-regulated Neuronal Phosphoprotein, PPP1R1B) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s DARPP32 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF).Suitable for use in Immunofluorescence.
Dilution: Immunofluorescence: 1:100-1:200. Researchers should empirically determine the suitability of the PPP1R1B ppp1r1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PPP1R1B ppp1r1b product has the following accession number(s) (GI #21717548) (NCBI Accession #AAM76683.1) (Uniprot Accession #Q9UD71). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
DARPP-32 is a dopamine (DA) and cAMP-regulated 32k phosphoprotein that is associated with dopaminoceptive neurons (Fienberg et al., 1998). The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA (Bibb et al., 1999). Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac (Maldve et al., 2002; Lindskog et al., 2002; Svenningsson et al., 2002).
Immunogen: Synthetic phosphopeptide corresponding to human DARPP-32 around the phosphorylation site of threonine 75 (A-Y-TP-P-P). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PPP1R1B are readily searchable from our website. Different antibodies against the same target such as PPP1R1B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Brain, Eye, Heart, Lung, Muscle, Nerve, Placenta, Prostate, Stomach tissues are correlated with this protein. Brain Diseases, Cognition Disorders, Disease Models, Animal, Dyskinesia, Drug-Induced, Dyskinesias, Movement Disorders, Nervous System Diseases, Neurotoxicity Syndromes, Parkinsonian Disorders, Substance-Related Disorders are some of the diseases may be linked to DARPP32, phosphorylated (Thr75) (Protein Phosphatase 1 Regulatory Subunit 1B, DARPP-32, Dopamine- and cAMP-regulated Neuronal Phosphoprotein, PPP1R1B).