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anti-PPPDE1 antibody product blog

Posted on 2015-07-19 21:51:31 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; PNAS4; anti-PPPDE1 antibody; PPPDE1;
The PPPDE1 desi2 (Catalog #MBS150332) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PNAS4 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s PNAS4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
PNAS4 antibody can be used for detection of PNAS4 by Western blot at 1 - 2 mug/mL. Researchers should empirically determine the suitability of the PPPDE1 desi2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The PPPDE1 desi2 product has the following accession number(s) (GI #38708309) (NCBI Accession #NP_057160) (Uniprot Accession #Q9BSY9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PNAS4 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of PNAS4 in EL4 cell lysate with PNAS4 antibody at (A) 1 and (B) 2 μg/mL.)
Western Blot (WB) PPPDE1.

PNAS4 Antibody: PNAS4 is a highly conserved protein that shares high homology from plants to animals. It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4. PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549. PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway. Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine. At least two isoforms of PNAS4 are known to exist.

Conjugate: Unconjugated
Immunogen: PNAS4 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human PNAS4.
Buffer: PNAS4 Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PPPDE1 are readily searchable from our website. Different antibodies against the same target such as PPPDE1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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