anti-Protein C Inhibitor (PCI, also called PAI-3) antibody product blog
Tags: Antibody; Polyclonal Antibody; Protein C Inhibitor (PCI, also called PAI-3); anti-Protein C Inhibitor (PCI, also called PAI-3) antibody;
The Protein C Inhibitor (PCI, also called PAI-3) n/a (Catalog #MBS512131) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase.Suitable as a source of enriched antibodies to human Protein C Inhibitor. Researchers should empirically determine the suitability of the Protein C Inhibitor (PCI, also called PAI-3) n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Protein C Inhibitor (PCI), also known as Plasminogen Activator Inhibitor 3 (PAI3), is a member of the SERPIN family of proteinase inhibitors. It is produced in the liver as a single chain glycoprotein (mass of 57 kDa) and circulates in plasma at a concentration of 5 ug/ml (~90 nM). PCI is also found in urine in lower concentrations of 250 ng/mL (~0.4 nM). PCI is the primary inhibitor of activated Protein C (APC) in plasma but demonstrates a relatively broad specificity, also inhibiting thrombin, FXa, FXIa, kallikrein, tPA, urokinase, prostate specific antigen, acrosin, chymotrypsin and trypsin. The preferred enzyme target for PCI appears to be thrombin and this interaction is increased by more than 100 fold in the presence of thrombomodulin. Like ATIII and HCII, the inhibitory activity of PCI towards some of these enzymes is stimulated by high concentrations of heparin (5 U/ml) which can accelerate the rate of inactivation as much as 50 fold. Enzyme inhibition by PCI occurs through proteolytic cleavage at Arg354-Ser355 and subsequent rapid formation of a stable, inactive 1:1 enzyme-PCI complex. Interaction with APC results in an SDS-stable APC-PCI complex of 102 kDa1-4.
Immunogen: Human Protein C Inhibitor purified from plasma. Buffer: 10 mM HEPES, pH 7.4, 150 mM NaCl, 50% (v/v) glycerol.
Neutralizing Activity: Not determined. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Protein C Inhibitor (PCI, also called PAI-3) are readily searchable from our website. Different antibodies against the same target such as Protein C Inhibitor (PCI, also called PAI-3) may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.