|The PRSS12 prss12 (Catalog #MBS150097) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Neurotrypsin Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Neurotrypsin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).
Neurotrypsin antibody can be used for detection of neurotrypsin by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the PRSS12 prss12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PRSS12 prss12 product has the following accession number(s) (GI #2661424) (NCBI Accession #CAA04816) (Uniprot Accession #P56730). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Neurotrypsin Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of neurotrypsin in SK-N-SH cell lysate with neurotrypsin antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.)
Immunohistochemistry (IHC) (Immunohistochemistry of Neurotrypsin in human brain tissue with Neurotrypsin antibody at 2.5 μg/mL.)
Immunofluorescence (IF) (Immunofluorescence of Neurotrypsin in Human Brain cells with Neurotrypsin antibody at 20 μg/mL.)
Neurotrypsin Antibody: Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.
Immunogen: Neurotrypsin antibody was raised against a 23 amino acid synthetic peptide from near the amino terminus of human neurotrypsin.
Buffer: Neurotrypsin Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PRSS12 are readily searchable from our website. Different antibodies against the same target such as PRSS12 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.