anti-PS1 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-PS1 antibody; PS1; Presenilin 1,2;
The PS1 n/a (Catalog #MBS6000522) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Presenilin 1,2, CT (Presenilin-1, PS-1, Protein S182, Presenilin-1 NTF Subunit, Presenilin-1 CTF Subunit, Presenilin-1 CTF12, PS1-CTF12, AD3, PS1, PSNL1, PSEN1/PSEN2, PS-2, STM-2, E5-1, AD3LP, AD5, Presenilin-2 NTF Subunit, Presenilin-2 CTF Subunit, AD4, reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Presenilin 1,2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC).Suitable for use in Western Blot, ELISA and Immunohistochemistry.
Dilution: ELISA: 1:1000
Western Blot: 1:100-1:500
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml. Researchers should empirically determine the suitability of the PS1 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PS1 n/a product has the following accession number(s) (GI #15223879) (NCBI Accession #NP_172346.1) (Uniprot Accession #O64668). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Presenilin 1,2, CT (Presenilin-1, PS-1, Protein S182, Presenilin-1 NTF Subunit, Presenilin-1 CTF Subunit, Presenilin-1 CTF12, PS1-CTF12, AD3, PS1, PSNL1, PSEN1/PSEN2, PS-2, STM-2, E5-1, AD3LP, AD5, Presenilin-2 NTF Subunit, Presenilin-2 CTF Subunit, AD4, with the following immunoassay(s):
Immunohistochemistry (IHC) (Human Placenta (formalin-fixed, paraffin-embedded) stained with PSEN1 antibody followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Western Blot (WB) (Western blot analysis of Hela cell line lysate (35ug/lane).)
Alzheimer\'s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Immunogen: Synthetic peptide corresponding to 10-30aa human PSN1/2 at C-terminal (KLH).