|The PSENEN psenen (Catalog #MBS5301864) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Psenen antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Psenen can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Optimal conditions to be determined by the end user. Researchers should empirically determine the suitability of the PSENEN psenen for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PSENEN psenen product has the following accession number(s) (GI #16307000) (NCBI Accession #AAH09575.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Psenen antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot showing Psenen antibody used at a concentration of 1.0 ug/ml against Mouse Heart Lysate)
Affinity purified rabbit polyclonal Psenen antibody.
Biological Significance: Psenen is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. Immunogen: Psenen antibody was raised in rabbit using the N terminal of Psenen as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PSENEN are readily searchable from our website. Different antibodies against the same target such as PSENEN may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Breast Neoplasms, Hidradenitis suppurativa, familial, Necrosis, Vascular Diseases are some of the diseases may be linked to Psenen antibody. Blood, Bone, Brain, Embryonic Tissue, Kidney, Ovary, Pharynx, Skin, Testis, Uncharacterized Tissue tissues are correlated with this protein. PSENEN also interacts with the following gene(s): APH1B, NCSTN, NOTCH1, PSEN1, PSEN2.