anti-PSMD10 antibody product blog
Tags: Antibody; Polyclonal Antibody; PSMD10; anti-PSMD10 antibody; 26S proteasome non-ATPase regulatory subunit 10;
The PSMD10 psmd10 (Catalog #MBS1498039) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human 26S proteasome non-ATPase regulatory subunit 10 polyclonal Antibody(PSMD10), HRP conjugated reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s 26S proteasome non-ATPase regulatory subunit 10 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the PSMD10 psmd10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The PSMD10 psmd10 product has the following accession number(s) (GI #4506217) (NCBI Accession #NP_002805.1) (Uniprot Accession #O75832). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
Storage Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate: HRP. Immunogen: Recombinant human 26S proteasome non-ATPase regulatory subunit 10 protein(1-226AA)
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-28479 / sc-8991. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PSMD10 are readily searchable from our website. Different antibodies against the same target such as PSMD10 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.