anti-PTCH1 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-PTCH1 antibody; PTCH1; Patched;
The PTCH1 ptch1 (Catalog #MBS6009431) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Patched, CT (PTCH, PTC, BCNS, FLJ42602, FLJ26746, Holoprosencephaly 7, HPE7, NBCCS, Patched 1, Patched Homolog 1, Protein Patched Homolog 1, PTC1, PTCH1, PTCH11) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Patched can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunohistochemistry (IHC).Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:8000
Immunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml. Researchers should empirically determine the suitability of the PTCH1 ptch1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PTCH1 ptch1 product has the following accession number(s) (GI #1381236) (NCBI Accession #AAC50550.1) (Uniprot Accession #Q13635). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Patched, CT (PTCH, PTC, BCNS, FLJ42602, FLJ26746, Holoprosencephaly 7, HPE7, NBCCS, Patched 1, Patched Homolog 1, Protein Patched Homolog 1, PTC1, PTCH1, PTCH11) with the following immunoassay(s):
Immunohistochemistry (IHC) (Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC) (Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE))
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. This gene functions as a tumor suppressor. Mutations of this gene have been associated with nevoid basal cell carcinoma syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
Immunogen: Synthetic peptide corresponding to ELQDVECEERPR from C-terminus of human PTCH1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PTCH1 are readily searchable from our website. Different antibodies against the same target such as PTCH1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.