anti-PTPN11 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-PTPN11 antibody; PTPN11; PTPN11 / SHP-2 / NS1;
The PTPN11 ptpn11 (Catalog #MBS241307) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human PTPN11 / SHP-2 / NS1 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s PTPN11 / SHP-2 / NS1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB).IHC-P (5 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.. Researchers should empirically determine the suitability of the PTPN11 ptpn11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PTPN11 ptpn11 product has the following accession number(s) (GI #33356177) (NCBI Accession #NP_002825.3) (Uniprot Accession #Q06124). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit Polyclonal to Human PTPN11 / SHP-2 / NS1 with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-PTPN11 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Western Blot (WB) (Western blot of SHP2 in mouse skeletal muscle tissue lysate with SHP2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.)
SHP2, a NT2 non-receptor protein tyrosine phosphatases, contains two tandem SRC homology (SH2) domains at the N-terminus of the catalytic domain. Based on crystallographic studies, the SH2 domain is believed to function as a conformational switch which can bind and inhibit the phosphatase or bind phosphoprotein and activate the enzyme. SHP2 is thought to link growth factor receptors and other signalling proteins via protein-tyrosine phosphorylation.
Target Species: Human
Immunogen Description: Synthetic peptide from human PTPN11. Immunogen Type: Synthetic peptide
Immunogen: PTPN11 / SHP-2 / NS1 antibody was raised against synthetic peptide from human PTPN11.
Antigen Modification: C-Terminus. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PTPN11 are readily searchable from our website. Different antibodies against the same target such as PTPN11 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.