|The PTPN22 ptpn22 (Catalog #MBS2529040) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTPN22 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s PTPN22 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).
IHC: 1:50-1:200. Researchers should empirically determine the suitability of the PTPN22 ptpn22 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PTPN22 ptpn22 product has the following accession number(s) (GI #47938186) (NCBI Accession #AAH71670.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PTPN22 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of Jurkat cell lines, using PTPN22 antibody.)
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracell?lar phosphatase that associates with the molec?lar adapter protein CBL and may be involved in reg?lating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves\' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Immunogen: Recombinant protein of human PTPN22
Calculated MW: 92kDa
Observed MW: Refer to Figures. Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PTPN22 are readily searchable from our website. Different antibodies against the same target such as PTPN22 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. PTPN22 also interacts with the following gene(s): CSK, CTLA4, DQB1-02, LCK, PADI4, SKAP2, STAT4. Arthritis, Rheumatoid, Autoimmune Diseases, Diabetes Mellitus, Type 1, Graves Disease, Immune System Diseases, Inflammation, Inflammatory Bowel Diseases, Lung Diseases, Lupus Erythematosus, Systemic, Necrosis are some of the diseases may be linked to PTPN22 Antibody. Blood, Bone Marrow, Brain, Connective Tissue, Lymph Node, Muscle, Pancreas, Skin, Thymus, Thyroid tissues are correlated with this protein.