anti-PTPN6 antibody product blog
Tags: Antibody; Polyclonal Antibody; PTPN6; anti-PTPN6 antibody;
The PTPN6 ptpn6 (Catalog #MBS2529895) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTPN6 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s PTPN6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC).WB: 1:200-1:1000
IHC: 1:50-1:200. Researchers should empirically determine the suitability of the PTPN6 ptpn6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PTPN6 ptpn6 product has the following accession number(s) (GI #2289910) (NCBI Accession #AAC36009.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PTPN6 Polyclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of A375 and A431 cell using PTPN6 Polyclonal Antibody at dilution of 1:500)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human colon cancer using PTPN6 Polyclonal Antibody at dilution of 1:35)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human liver cancer using PTPN6 Polyclonal Antibody at dilution of 1:35)
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
Immunogen: Recombinant protein of human PTPN6
Calculated Molecular Weight: 68kDa. Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PTPN6 are readily searchable from our website. Different antibodies against the same target such as PTPN6 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.