anti-RAC2 antibody product blog
Tags: Antibody; Polyclonal Antibody; RAC2; anti-Rac2 antibody;
The RAC2 rac2 (Catalog #MBS9405791) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RAC2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s RAC2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Western blotting: 1:500 - 1:2000. Researchers should empirically determine the suitability of the RAC2 rac2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The RAC2 rac2 product has the following accession number(s) (GI #4506381) (NCBI Accession #NP_002863.1) (Uniprot Accession #P15153). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the RAC2 antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of Jurkat cell and HL-60 cell lysate using RAC2 antibody.)
Rac and Cdc42 are members of the Rho-GTPase family. In mammals, Rac exists as three isoforms, Rac1, Rac2 and Rac3, which are highly similar in sequence. Rac1 and Cdc42, the most widely studied of this group, are ubiquitously expressed. Rac2 is expressed in cells of hematopoietic origin, and Rac3, while highly expressed in brain, is also found in many other tissues. Rac and Cdc42 play key signaling roles in cytoskeletal reorganization, membrane trafficking, transcriptional regulation, cell growth and development (1). GTP binding stimulates the activity of Rac/Cdc42, and the hydrolysis of GTP to GDP through the protein\'s intrinsic GTPase activity, rendering it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs). Another level of regulation is achieved through the binding of RhoGDI, a guanine nucleotide dissociation inhibitor, which retains Rho family GTPases, including Rac and Cdc42, in their inactive GDP-bound state (2,3).
Immunogen Type: Recombinant Protein
Immunogen Description: Recombinant protein of human RAC2. Target Name: RAC2. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing RAC2 are readily searchable from our website. Different antibodies against the same target such as RAC2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Bone Marrow, Brain, Eye, Heart, Liver, Lung, Spleen, Vascular tissues are correlated with this protein.