anti-RBX1 antibody product blog
Tags: Antibody; Polyclonal Antibody; Rbx1; anti-RBX1 antibody;
The RBX1 rbx1 (Catalog #MBS9404817) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RBX1 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s RBX1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF).Western blotting: 1:500 - 1:2000
Immunofluorescence: 1:50 - 1:200. Researchers should empirically determine the suitability of the RBX1 rbx1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The RBX1 rbx1 product has the following accession number(s) (GI #7657508) (NCBI Accession #NP_055063.1) (Uniprot Accession #P62877). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the RBX1 antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of various cell lines, using RBX1 antibody.)
Immunofluorescence (IF) (Immunofluorescence analysis of MCF7 cell using RBX1 antibody. Blue: DAPI for nuclear staining.)
RING-box protein 1 (RBX1 or ROC1) is an essential component of two distinct but structurally related E3 ubiquitin ligase complexes, the SCF complex and the CBC (VHL) complex (1). RBX1 mediates the neddylation of CUL1, which activates SCF E3 ligase by facilitating the ubiquitin transfer from E2 to substrates (2-4). The RING finger domain of RBX1 is required for ubiquitin ligation (5). Two evolutionarily conserved mammalian RBX family members, RBX1/ROC1 and RBX2/ROC2/SAG, have been identified (5). RBX1 is constitutively expressed and binds to CUL2/VHL, while stress-inducible RBX2 binds to CUL5/SOCS (6).
Immunogen Type: Recombinant Protein
Immunogen Description: Recombinant protein of human RBX1. Target Name: RBX1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing RBX1 are readily searchable from our website. Different antibodies against the same target such as RBX1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. Adenocarcinoma, Carcinoma, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Inflammation, Kidney Diseases, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Nervous System Diseases are some of the diseases may be linked to RBX1 antibody. The following patways have been known to be associated with this gene.