anti-RIMS3 antibody product blog
Tags: Antibody; Polyclonal Antibody; Rim3; RIMS3; anti-RIMS3 antibody;
The RIMS3 rims3 (Catalog #MBS619429) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rim3, NT (Rab3-interacting molecule 3, regulating synaptic membrane exocytosis 3, RIM3 gamma, RIMS3, NIM3) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Rim3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in Elisa and Western Blot.
Dilution: Western Blot: 0.5-1ug/ml. Researchers should empirically determine the suitability of the RIMS3 rims3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The RIMS3 rims3 product has the following accession number(s) (GI #48476344) (NCBI Accession #NP_055562.2) (Uniprot Accession #Q9UJD0). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rim3, NT (Rab3-interacting molecule 3, regulating synaptic membrane exocytosis 3, RIM3 gamma, RIMS3, NIM3) with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of Rim3 in human brain tissue lysate with Rim3 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.)
Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neural transmission and plasticity (1,2). While both Rim1 and Rim 2 are thought to be effector proteins for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner, less is known of Rim3. Expression of Rim3 in PC12 cells induced a significant increase in calcium-triggered exocytosis, with no appreciable change in the baseline release, suggesting that it plays a role in the regulation of exocytosis (1). Rim3 protein localizes primarily to neuronal dendrites and the postsynaptic densities, as opposed to Rim1 which is found in presynapse locations, indicating that Rim3 may contribute to synapse transmission and plasticity (2). This antibody is predicted to have no cross-reactivity to other Rim proteins.
Immunogen: Synthetic peptide corresponding to 17aa from near the amino terminus of human Rim3 (GenBank accession no. NP_055562). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing RIMS3 are readily searchable from our website. Different antibodies against the same target such as RIMS3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.