anti-Rps6ka5 antibody product blog
Tags: Antibody; Polyclonal Antibody; RPS6KA5; anti-RPS6KA5 antibody; Mouse Rps6ka5;
The Rps6ka5 rps6ka5 (Catalog #MBS9204496) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Mouse Rps6ka5 Antibody (C-term) reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Rps6ka5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).WB~~1:4000. Researchers should empirically determine the suitability of the Rps6ka5 rps6ka5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Rps6ka5 rps6ka5 product has the following accession number(s) (GI #23956386) (NCBI Accession #NP_705815.1) (Uniprot Accession #Q8C050). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse Rps6ka5 Antibody (C-term) with the following immunoassay(s):
Western Blot (WB) (Anti-Rps6ka5 Antibody (C-term)at 1:4000 dilution + mouse heart lysates
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution
Predicted band size : 97 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.)
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at \'Ser-276\' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the \'Ser-727\' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at \'Ser-191\' and \'Ser-216\', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of \'Ser-1\' of histone H2A. Phosphorylates \'Ser-10\' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto- oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate \'Ser-28\' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro- inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti- inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.