anti-RPSA antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-RPSA antibody; RPSA; 40S ribosomal protein SA;
The RPSA rpsa (Catalog #MBS7006102) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human 40S ribosomal protein SA polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s 40S ribosomal protein SA can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).Recommended dilution: WB:1:500-2000. Researchers should empirically determine the suitability of the RPSA rpsa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The RPSA rpsa product has the following accession number(s) (GI #747165389) (NCBI Accession #NP_001291217.1) (Uniprot Accession #P08865). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit anti-human 40S ribosomal protein SA polyclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot
All lanes: 40S ribosomal protein SA antibody at 2ug/ml+mouse small intestineSecondary
Goat polyclonal to Rabbit lgG at 1/15000 dilution
Predicted band size: 33kDa
Observed band size: 33kDa
)
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.